Corneal Disease

Structure of the CorneaThe cornea is the eye’s outermost layer.  It is the clear, dome-shaped surface that covers the front of the eye.  Several diseases affect the cornea, either directly or as part of a system-wide problem. Often serious, these conditions require immediate attention by an ophthalmologist to preserve your vision.

Corneal Infections

Sometimes the cornea is contaminated after a foreign body has penetrated the tissue, such as a branch.  At other times, bacteria or fungi from an old contact lens can pass into the cornea.

Situations like these can cause painful inflammation and corneal infections called keratitis. These infections can reduce visual clarity, produce corneal discharge, and perhaps erode the cornea. Corneal infections can also lead to corneal scarring, which can impair vision and may require a corneal transplant.  As a general rule, the deeper the corneal infection, the more severe the symptoms and complications.  It should be noted that corneal infections, although relatively infrequent, are the most serious complication of contact lens wear.  Minor corneal infections are commonly treated with anti-bacterial eye drops.  If the problem is severe, it may require more intensive antibiotic or anti-fungal treatment to eliminate the infection, as well as steroid eye drops to reduce inflammation and the risk of scarring.  Frequent visits to an eye care professional may be necessary for several months to eliminate the problem.

Dry Eye

In people with dry eye, the eye produces fewer or lower quality tears and is unable to keep its surface lubricated and comfortable. The continuous production and drainage of tears is important to the eye’s health.  Tears keep the eye moist, help wounds heal, and protect against eye infection.

Fuchs’ Dystrophy

Fuchs’ dystrophy is a slowly progressing disease that usually affects both eyes and is more common in women than in men.  Although doctors can often see early signs of Fuchs’ dystrophy in people in their 30s and 40s, the disease rarely affects vision until people reach their 50s and 60s.

Fuchs’ dystrophy occurs when endothelial cells gradually deteriorate without any apparent reason.  As more endothelial cells are lost over the years, the endothelium becomes less efficient at pumping water out of the stroma.  This causes the cornea to swell and distort vision.  Eventually, the epithelium also takes on water, resulting in pain and severe visual impairment.  Epithelial swelling damages vision by changing the cornea’s normal curvature, and causing a sight-impairing haze to appear in the tissue.  Epithelial swelling will also produce tiny blisters on the corneal surface, and when these blisters burst, they are extremely painful.

At first, a person with Fuchs’ dystrophy will awaken with blurred vision that will gradually clear during the day.  This occurs because the cornea is normally thicker in the morning; it retains fluids during sleep that evaporate in the tear film while we are awake.  As the disease worsens, this swelling will remain constant and reduce vision throughout the day.

When treating the disease, doctors will try first to reduce the swelling with drops, ointments, or soft contact lenses.  They also may instruct a person to use a hair dryer, held at arm’s length or directed across the face, to dry out the epithelial blisters.  This can be done two or three times a day.

When the disease interferes with daily activities, a person may need to consider having a corneal transplant to restore sight. The short-term success rate of corneal transplantation is quite good for people with Fuchs’ dystrophy. However, some studies suggest that the long-term survival of the new cornea can be a problem.

Corneal Dystrophies

A corneal dystrophy is a condition in which one or more parts of the cornea lose their normal clarity due to a buildup of cloudy material.  There are over 20 corneal dystrophies that affect all parts of the cornea. These diseases share many traits:

  • They are usually inherited.
  • They affect both eyes equally.
  • They are not caused by outside factors, such as injury or diet.
  • Most progress gradually.
  • Most usually begin in one of the five corneal layers and may later spread to nearby layers.
  • Most do not affect other parts of the body, nor are they related to diseases affecting other parts of the eye or body.
  • Most can occur in otherwise totally healthy people, male or female.

Corneal dystrophies affect vision in many different ways.  Some cause severe visual impairment, while a few cause no vision problems and are discovered during a routine eye examination.  Other dystrophies may cause repeated episodes of pain without leading to permanent loss of vision.  Some of the most common corneal dystrophies include Fuchs’ dystrophy, keratoconus, lattice dystrophy, and map-dot-fingerprint dystrophy.


This disorder is a progressive thinning of the cornea and is the most common corneal dystrophy in the U.S., affecting one in every 2000 Americans.  It is more prevalent in teenagers and adults in their 20s.  Keratoconus arises when the middle of the cornea thins and gradually bulges outward, forming a rounded cone shape.  This abnormal curvature changes the cornea’s refractive power, producing moderate to severe distortion (astigmatism) and blurriness (nearsightedness) of vision.  Keratoconus may also cause swelling and a sight-impairing scarring of the tissue.

Studies indicate that keratoconus stems from one of several possible causes:

  • An inherited corneal abnormality.  About seven percent of those with the condition have a family history of keratoconus.
  • An eye injury, i.e., excessive eye rubbing or wearing hard contact lenses for many years.
  • Certain eye diseases, such as retinitis pigmentosa, retinopathy of prematurity, and vernal keratoconjunctivitis.
  • Systemic diseases, such as Leber’s congenital amaurosis, Ehlers-Danlos syndrome, Down syndrome, and osteogenesis imperfecta.

Keratoconus affects both eyes but often asymmetrically.  At first, people can correct their vision with eyeglasses.  But as the astigmatism worsens, they must rely on specially fitted contact lenses to reduce the distortion and provide better vision.  Although finding a comfortable contact lens can be an extremely frustrating and difficult process, it is crucial because a poorly fitting lens could further damage the cornea and make wearing a contact lens intolerable.

In most cases, the cornea will stabilize after a few years without ever causing severe vision problems.  But in about 10 to 20 percent of people with keratoconus, the cornea will eventually become too scarred or will not tolerate a contact lens.  If either of these problems occur, a corneal transplant may be needed.  This operation is successful in more than 95 percent of those with advanced keratoconus.  Several studies have also reported that 90 percent or more of these patients have 20/40 vision or better after the operation.

Herpes Zoster (Shingles)

This infection is produced by the varicella-zoster virus, the same virus that causes chickenpox.  After an initial outbreak of chickenpox (often during childhood), the virus remains inactive within the nerve cells of the central nervous system.  But in some people, the varicella-zoster virus will reactivate at another time in their lives.  When this occurs, the virus travels down long nerve fibers and infects some part of the body, producing a blistering rash (shingles), fever, painful inflammations of the affected nerve fibers, and a general feeling of sluggishness.

Varicella-zoster virus may travel to the head and neck, perhaps involving an eye, part of the nose, cheek, and forehead.  In about 40 percent of those with shingles in these areas, the virus infects the cornea.  Doctors will often prescribe oral anti-viral treatment to reduce the risk of the virus infecting cells deep within the tissue, which could inflame and scar the cornea.  The disease may also cause decreased corneal sensitivity, meaning that foreign matter, such as eyelashes, in the eye are not felt as keenly.  For many, this decreased sensitivity will be permanent.

Although shingles can occur in anyone exposed to the varicella-zoster virus, research has established two general risk factors for the disease: (1) Advanced age; and (2) A weakened immune system.  Unlike herpes simplex I, the varicella-zoster virus does not usually flare up more than once in adults with normally functioning immune systems.  Be aware that corneal problems may arise months after the shingles are gone. For this reason, it is important that people who have had facial shingles schedule follow-up eye examinations.

Ocular Herpes

Herpes of the eye, or herpes simplex keratitis, is a recurrent viral infection that is caused by the herpes simplex virus and is the most common infectious cause of corneal blindness in the U.S.  Previous studies show that once people develop ocular herpes, they have up to a 50 percent chance of having a recurrence.  This second flare-up could come weeks or even years after the initial occurrence.

Ocular herpes can produce a painful sore on the eyelid or surface of the eye and cause inflammation of the cornea.  Prompt treatment with anti-viral drugs helps to stop the herpes virus from multiplying and destroying epithelial cells.  However, the infection may spread deeper into the cornea and develop into a more severe infection called stromal keratitis, which causes the body’s immune system to attack and destroy stromal cells.  Stromal keratitis is more difficult to treat than less severe ocular herpes infections.  Recurrent episodes of stromal keratitis can cause scarring of the cornea, which can lead to loss of vision and possibly blindness.

Like other herpetic infections, herpes of the eye can be controlled.  An estimated 400,000 Americans have had some form of ocular herpes.  Each year, nearly 50,000 new and recurring cases are diagnosed in the United States, with the more serious stromal keratitis accounting for about 25 percent.  In one large study, researchers found that recurrence rate of ocular herpes was 10 percent within one year, 23 percent within two years, and 63 percent within 20 years.  Some factors believed to be associated with recurrence include fever, stress, sunlight, and eye injury.


A pterygium is a pinkish, triangular-shaped tissue growth on the cornea.  Some pterygia grow slowly throughout a person’s life, while others stop growing after a certain point.  A pterygium rarely grows so large that it begins to cover the pupil of the eye.

Pterygia are more common in sunny climates and in the 20-40 age group.  Many doctors believe ultraviolet (UV) light from the sun may be a factor.  In areas where sunlight is strong, wearing protective eyeglasses, sunglasses, and/or hats with brims are suggested.  While some studies report a higher prevalence of pterygia in men than in women, this may reflect different rates of exposure to UV light.

Because a pterygium is visible, many people want to have it removed for cosmetic reasons.  It is usually not too noticeable unless it becomes red and swollen from dust or air pollutants.  Surgery to remove a pterygium is not recommended unless it affects vision or causes chronic irritation.  Lubricants can reduce the redness and provide relief from the chronic irritation.  When a pterygium is surgically removed using the latest techniques, it rarely grows back.

the cornea specialists in denver, co

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